Background academic articles

The TGT pathway is relatively new, previously undrugged and can appear somewhat esoteric with its role in the selective modification of specific tRNAs and consequential epigenetic control over cells. As an aid to researchers and anyone else interested in the area we have compiled a list of links to academic articles.

These are primarily, but not exclusively, by the Azadyne Founders. The majority of information on the pathway and the selective control over cell differentiation and proliferation is proprietary, however we are open to confidential discussions with interested parties. Please contact us via the website contact button.

The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity

Nucleic Acids Research, 2021, Vol. 49, No. 9 4877–4890 doi: 10.1093/nar/gkab289

The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi–bi mechanism

Chem. Commun., 2020, 56, 3915

In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

Nucleic Acids Research, 2017, Vol. 45, No. 4 2029–2039 doi: 10.1093/nar/gkw847

The Queuine Micronutrient: Charting a Course from Microbe to Man

Nutrients 2015, 7, 2897-2929; doi:10.3390/nu7042897

Queuosine Formation in Eukaryotic tRNA Occurs via a Mitochondria-localized Heteromeric Transglycosylase

THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL.284,NO.27,pp.18218–18227, July3, 2009

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells

Nutrients 2020, 12, 871; doi:10.3390/nu12030871