Background academic articles
The TGT pathway is relatively new, previously undrugged and can appear somewhat esoteric with its role in the selective modification of specific tRNAs and consequential epigenetic control over cells. As an aid to researchers and anyone else interested in the area we have compiled a list of links to academic articles.
These are primarily, but not exclusively, by the Azadyne Founders. The majority of information on the pathway and the selective control over cell differentiation and proliferation is proprietary, however we are open to confidential discussions with interested parties. Please contact us via the website contact button.
The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity
Nucleic Acids Research, 2021, Vol. 49, No. 9 4877–4890 doi: 10.1093/nar/gkab289
The eukaryotic tRNA-guanine transglycosylase enzyme inserts queuine into tRNA via a sequential bi–bi mechanism
Chem. Commun., 2020, 56, 3915
In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis
Nucleic Acids Research, 2017, Vol. 45, No. 4 2029–2039 doi: 10.1093/nar/gkw847
The Queuine Micronutrient: Charting a Course from Microbe to Man
Nutrients 2015, 7, 2897-2929; doi:10.3390/nu7042897
Queuosine Formation in Eukaryotic tRNA Occurs via a Mitochondria-localized Heteromeric Transglycosylase
THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL.284,NO.27,pp.18218–18227, July3, 2009
Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells
Nutrients 2020, 12, 871; doi:10.3390/nu12030871